![]() ![]() In this respect, a total of 80 patients diagnosed with TNBC were identified during the assigned period, from which clinic demographic characteristics were inadequate in 22 patients. Patients with incomplete clinical or demographic characteristics were excluded from the study. The clinical and demographic characteristics of the patients were extracted from their medical files. In a retrospective cohort study, formalin-fixed paraffin-embedded (FFPE) tumor tissues from patients diagnosed with TNBC who underwent surgical treatment at our center (Imam Hossein Hospital, Tehran, Iran) between 20 were collected. To shed more light on this proposed stratification role, we aimed to investigate how the expression of PRLR is associated with the tumor characteristics in TNBC. Accordingly, they suggested a potential new modality for TNBC stratification using the component of the PRL pathway. A recent study has introduced PRL and its receptor as a sub classified predictor of pro-differentiation therapy in TNBC. In this respect, the expression of PRLR has been found to correlate with a favorable prognosis of breast cancer in some investigations. While many investigations have highlighted the role of PRLR in promoting breast cancer tumorigenesis, other studies have suggested a potential suppressor role for PRLR in breast carcinogenesis. Prolactin is a hormone secreted mainly by the anterior pituitary gland and induces its signaling cascade through dimerization with PRLR. Association of prolactin with several tumors is identified. A better understanding of this heterogeneity may provide new opportunities for better stratification of patients, giving rise to a personalized, less aggressive treatment for those patients with superior prognostic criteria. PRLR is one of the most controversial biomarkers in this field. In groups of patients with different prognoses, many attempts have recently been made to use molecular profiles and sub classifications of TNBC patients to find patients who are candidates for more aggressive treatment approaches. Patients without lymph node involvement have a 30% chance of recurrence, while in patients with lymph node involvement, there is a 75% chance of recurrence. Lymph node involvement is a significant predictor. The most important of these are the causes of smoking, obesity, lymph node involvement, estrogen and progesterone receptors, epidermal growth factor 2 receptors, protein p 53 human epidermal growth factor receptor-2 (HER-2) and prolactin receptor (PRLR). The prognosis of breast cancer depends on several factors. ![]() Studies on the biology of TNBC have revealed that it is a heterogeneous disease with diverse behavior. This subtype of breast cancer is seen in approximately 10–20% of all people living with breast cancer and is associated with a poor prognosis and a higher risk of recurrence and death. ![]() Triple-negative breast cancer (TNBC) is defined by a lack of expression of estrogen and progesterone receptors and human epidermal growth factor receptors. Worldwide, breast cancer is the second leading cause of cancer death in women. ![]()
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